Discussing a harm reduction approach will be the focus of this series. Many programs today say they use a harm reduction approach. But what does “harm reduction” actually mean in most social service settings? Is it only about substance use, or can the principles be applied to other behaviors? What is the difference between a harm reduction philosophy and harm reduction programs? All of these questions will be answered and discussed in this series. Examples of harm reduction in various settings and with various populations will be discussed.